Journal of Clinical and Aesthetic Dermatology

DEC 2017

An evidence-based, peer-reviewed journal for practicing clinicians in the field of dermatology

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35 JCAD JOURNAL OF CLINICAL AND AESTHETIC DERMATOLOGY December 2017 • Volume 10 • Number 12 O R I G I N A L R E S E A R C H well when applied daily according to the schedule in Table 3. The percentage of subjects who reported improvement in one or more of their skin attributes ranged from 84 to 97 percent. Subjects evaluated lines and wrinkles, softness, smoothness, radiance and brightness, and overall improvement. Advantages of this study include high rate of survey completion (91%) and large number of reporting subjects (n=222). The five products provided a comprehensive anti-aging treatment for the face, eye, and lip areas, which age at different rates. Products were applied in the morning, evening, or both. It is important to note that 90 percent of subjects reported each of the five products absorbed well into their skin within three minutes of application. This observation, along with the continuous and progressive improvement in most parameters in the 56-day study, show that the early absorption of products into the skin is genuine rather than superficial, and that the beneficial effects of the products continue to increase despite regular cleaning of the face. The likelihood of recommending one or more of these products in the future ranged from 57 percent (Group 4) to 91 percent (Group 1). The low percentage of Group 4 is, again, attributed to the reduced clinical performance of the day lip cream versus the night lip cream. Values in the remaining groups were 87 percent (Group 5), 84 percent (Group 3), and 80 percent (Group 2), respectively. CONCLUSIONS Although the 56-day trial included only five subjects for each test product, the improvements in endpoints from baseline to the end of the study were extremely high and achieved 95-percent confidence levels for all test products. Results of this study support the effectiveness of the facial, eye, and lip creams used in this study as anti-aging products that reduce the appearance of both fine and coarse lines and wrinkles, increase the moisturization of the skin, and, in the case of the face and eye products, decrease transepidermal water loss. The test products showed early positive effects on the skin test sites, and these effects were see for at least 56 days without significant adverse effects. We attribute these results to the integration of the dermal delivery technology, the cross linked hyaluronic acid, and synthetically engineered natural collagen utilized by the test products. REFERENCES 1. Sercombe L, Veerati T, Moheimani F, et al. Advances and challenges of liposome assisted drug delivery. Front Pharmacol. 2015;6:286. 2. Agarwal S, Kumari PVK. Advances in Novasome technology - a review. Int J Appl Pharm. 2013;5: 1–4. 3. Pinsky MA, inventor. Materials and methods for delivering antioxidants into the skin. US Patent, filed 2010. 4. Singh A, Malviya R, Sharma PK. Novasome - a breakthrough in pharmaceutical technology: a review article. Adv Biol Res. 2011; 5:184–189. 5. Fischer TW, Wigger-Alberti W, Elsner P. Direct and non-direct measurement techniques for analysis of skin surface topography. Skin Pharmacol Appl Skin Physiol. 1999;12(1–2):1–11. 6. Seitz JC, Spencer TS. The use of capacitive evaporimetry to measure the effects of topical ingredients on transepidermal water loss (TEWL) [Abstract]. Clin Res. 1982;30:608A. 7. Leveque JL, de Rigal J. Impedance methods for studying skinmoisturization. J Soc Cosmet Chem. 1983;34(8):419–428. JCAD FIGURE 18. Percentage of subjects with an improvement in one or more skin attributes (e.g., hydration, softness, smoothness, radiance or brightness, lines and wrinkles, overall improvement) after using the test products for four weeks TABLE 5. Onset and duration of continued improvement in skin evaluation parameters with 5 topical test products PARAMETER DAY FACIAL CREAM NIGHT FACIAL CREAM EYE CREAM DAY LIP CREAM NIGHT LIP CREAM Onset SELS 15 minutes 15 minutes 15 minutes 15 minutes 15 minutes TEWL 28 days 15 minutes 14 days – – EC 15 minutes 15 minutes 15 minutes 15 minutes 15 minutes Duration SELS 56 days 56 days 56 days 56 days 56 days TEWL 56 days 56 days 56 days – – EC 56 days 56 days 56 days 56 days 56 days SELS: surface evaluation of living skin; TWEL: transepidermal water loss; EC: electroconductivity

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