Journal of Clinical and Aesthetic Dermatology

DEC 2017

An evidence-based, peer-reviewed journal for practicing clinicians in the field of dermatology

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34 JCAD JOURNAL OF CLINICAL AND AESTHETIC DERMATOLOGY December 2017 • Volume 10 • Number 12 O R I G I N A L R E S E A R C H Group 2 (95%), Group 5 (89%), Group 4 (85%), and Group 1 (84%). Willingness to recommend one or more of the products to a friend was greatest in Group 3 (97%), followed by Group 2 (95%), Group 1 (91%), Group 5 (90%), and Group 4 (62%). The low value (62%) for Group 4, in which both the day and night lip creams were used, might be attributed to the lesser clinical performance of the day lip cream in comparison with the superior performance of the night lip cream, as shown in Figures 15 and 16. Among the medical estheticians, 87 percent observed improvement in one or more of the same attributes in their subjects. Adverse effects. Adverse effects or unexpected reactions of any kind were not observed in any subject in the 56-day study or in the experience trial. DISCUSSION The 56-day study. The results show that with each of the five topical test products, improvement in SELS becomes noticeable to the measuring device within 15 minutes of the initial application and that improvement continues for at least 56 days with regular use (Table 5). To the author's knowledge, noticeable improvement in SELS within 15 minutes of application of the test product is unprecedented in cosmetic dermatology. Improvement was significant after 14 days and 28 days of use for the day facial cream; after 15 minutes, 28 days, and 56 days of use for the night facial cream; after seven days and 14 days of use for the eye cream; after seven days for the day lip cream; and after seven, 14, 28, and 56 days of use for the night lip cream. These results suggest that skin surface roughness, or the depth of fine and coarse lines and wrinkles, decreased immediately after product application and continued to decrease for at least 56 days with regular use of each test product. Similar but even more favorable trends are apparent with EC. Improvements were significant after 15 minutes, 14 days, and 28 days of use for the day facial cream; after every timepoint for the night facial cream and eye cream; and after 15 minutes for both the day lip cream and night lip cream. These results show that each of the five test products helped to increase the moisture content in the skin almost immediately after application and that the favorable trends continued for at least 56 days with regular use. These very early results and continuing improvement for at least 56 days have, to the author's knowledge, not been reported for any topical product. Improvement in TEWL (measured only in those using the facial and eye creams) was nearly immediate with the use of the night facial cream, at 14 days with the eye cream, and at 28 days with the day facial cream. Improvement was significant at 28 and 56 days for the night facial cream. The experience trial. The results (Figure 18) show that the selected products, which included facial, eye, and lip creams, performed FIGURE 15. A 53-year-old Caucasian woman at baseline (A) and after 56 days of treatment (B) with the day lip cream— Pixel data (61,786 at baseline and 8,519 at 56 days) show that the wrinkles on the bottom lip were reduced by 86.21% FIGURE 16. Changes in evaluation parameters for the night lip cream SELS: standard evaluation parameter; EC: electroconductivity FIGURE 17. A 46-year-old Caucasian woman at baseline (A) and after 56 days of treatment (B) with the night lip cream—Pixel data (74,894 at baseline and 19,678 at 56 days) show that the wrinkles on the bottom lip were reduced by 73.73%. A B A B

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