Journal of Clinical and Aesthetic Dermatology

DEC 2017

An evidence-based, peer-reviewed journal for practicing clinicians in the field of dermatology

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33 JCAD JOURNAL OF CLINICAL AND AESTHETIC DERMATOLOGY December 2017 • Volume 10 • Number 12 O R I G I N A L R E S E A R C H application and continued to decline during the remainder of the study period. The decrease as compared with at baseline was significant after seven days of use (p=0.046, -11.21%). A decrease in SELS as compared with at baseline (Table 4) was also evident as early as 15 minutes after (-16.79%) and reached a maximum at 56 days (-30.60%). EC increased dramatically at 15 minutes (63.82%, Figure 14), decreased at seven days (10.09%), and began an upward trend until 56 days (35.27%; Table 4). The increase was significant after seven days of use (p=0.014). A clinical example of a patient at baseline and after 56 days of treatment with the day lip cream is shown in Figure 15. Night lip cream. As shown in Figure 16, SELS started to decline 15 minutes after product application and continued to decline during the remainder of the study period. A decrease in SELS as compared with at baseline (Table 4) was also evident as early as 15 minutes (-11.87% difference) and reached a maximum at 56 days (-24.79%). The difference from baseline was significant after seven days (p=0.040, -7.40%), 14 days (p=0.018, -13.39%), 28 days (p=0.019, -17.70%), and 56 days of use (p=0.011, -24.79%). EC increased dramatically at 15 minutes (27.16%, Figure 16), decreased at seven days (1.50%), and began an upward trend that reached a maximum at 56 days (45.52%). The increase from baseline was significant at 15 minutes (p=0.003). A clinical example of a patient at baseline and after 56 days of treatment with the night lip cream is shown in Figure 17. The experience trial. Among the 244 enrolled subjects, 222 (91%) completed the survey at the end of the study. Serious adverse events were not observed. Most subjects (90%) reported that each of the five products absorbed well into their skin within three minutes of application and there were no objections to the scent of the products (they were fragrance-free). Subjects commented on improvement after one month of use for one or more of the following skin attributes: hydration, softness, smoothness, radiance or brightness, lines and wrinkles, and overall improvement. Among the five groups, the percentage of subjects citing improvement in one or more skin attributes after four weeks of use is shown in Figure 18. The highest was in Group 3 (97%), followed by FIGURE 11. Changes in evaluation parameters for the eye cream SELS: standard evaluation parameter; TEWL: transepidermal water loss; EC: electroconductivity FIGURE 12. A 42-year-old Caucasian woman at baseline (A) and after 42 days of treatment (B) with the eye cream—Pixel data (26,329 at baseline and 18,847 at 14 days) show that the wrinkles below the patient's eye were reduced by 28.42%. FIGURE 13. A 56-year-old Caucasian woman at baseline (A) and after 14 days of treatment (B) with the eye cream—Pixel data (30,769 at baseline and 24,859 at 42 days) show that the wrinkles to the left of the patient's eye were reduced by 19.21%. FIGURE 14. Changes in evaluation parameters for the day lip cream SELS: standard evaluation parameter; EC: electroconductivity A B A B

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