Journal of Clinical and Aesthetic Dermatology

DEC 2017

An evidence-based, peer-reviewed journal for practicing clinicians in the field of dermatology

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32 JCAD JOURNAL OF CLINICAL AND AESTHETIC DERMATOLOGY December 2017 • Volume 10 • Number 12 O R I G I N A L R E S E A R C H also evident as early as 15 minutes (-19.24% difference) and reached a maximum at 56 days (-45.19%). Differences from baseline were significant after seven days (p=0.024, -30.25% and 14 days (p=0.027, -40.40%) of use. TEWL readings (Figure 11) began to decrease after 14 days of test product use and continued up to 56 days. A decrease in TEWL as compared with baseline (Table 4) was evident at 14 days (-13.41%) and continued until 56 days (-21.15%). EC increased dramatically after 15 minutes (Figure 11), decreased at 14 days, and began an upward trend that reached a maximum above baseline at 56 days (75.49%; Table 4). Differences from baseline were significant after 15 minutes (p=0.001, 103.10%), seven days (p=0.002, 22.04%), 14 days (p=0.022, 26.67%), 28 days (p=0.045, 38.24%), and 56 days (p=0.009, 75.49%) of use. Clinical examples of patients at baseline and after 14 and 42 days of treatment with the eye cream are shown in Figures 12 and 13. Day lip cream. As shown in Figure 14, SELS started to decline 15 minutes after product FIGURE 8 . A 34-year-old Caucasian female at baseline (A) and after 28 days of treatment (B) with the night facial cream—Pixel data for site 1 (9,299 at baseline and 6,723 at 28 days) and site 2 (5,107 at baseline and 3,903 at 28 days) show that the wrinkles at Sites 1 and 2 were reduced by 27.70% and 23.58%, respectively. FIGURE 9. A 46-year-old Caucasian woman at baseline (A) and after 28 days of treatment (B) with the night facial cream—Pixel data (4,557 at baseline and 2.329 at 28 days) show that the vertical wrinkle was reduced by 48.89%. FIGURE 10. A 36-year-old Caucasian woman at baseline (A) and after 14 days of treatment (B) with the night facial cream—Pixel data (41,489 at baseline and 29,255 at 14 days) show that the wrinkle to the left of the patient's lip was reduced by 29.49%. To the author's knowledge, a topical technology that reduces the nasolabial fold and glabellar line to this extent in 14 days has not been reported. A A B B A B

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