Journal of Clinical and Aesthetic Dermatology

DEC 2017

An evidence-based, peer-reviewed journal for practicing clinicians in the field of dermatology

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28 JCAD JOURNAL OF CLINICAL AND AESTHETIC DERMATOLOGY December 2017 • Volume 10 • Number 12 O R I G I N A L R E S E A R C H increase skin moisturization, and decrease transepidermal water loss. The test products (skIN3; Alphaeon Corp., Irvine, California) were a day facial cream, a night facial cream, a eye cream, a day lip cream, and a night lip cream, each using the DermaTriPlex technology platform. METHODS Two studies were performed: a 56-day controlled clinical trial for each individual test product and an experience trial involving more than 200 patients using a strategic combination of products. The 56-day study. In the first study, female subjects (n=5) were enrolled in each of the five studies. Subjects were recruited by advertisements in local periodicals, community bulletin boards, phone solicitation, and electronic media. Demographic data are shown in Table 1. Inclusion criteria were healthy women aged 35 to 60 years for the facial and eye creams, and Caucasian women aged 35 to 55 years for the lip creams. Subjects were asked to abstain from the use of any anti-aging and moisturizing products, including lotions, creams, gels, and nutritional supplements for at least eight weeks prior to the study. Each of the subjects exhibited fine lines and wrinkles at the test site and abstained from using any anti-aging products or moisturizing products on the lips or surrounding area (e.g., lotions, creams, lipsticks, chapsticks, gels, nutritional supplements) for at least 72 hours prior to the start of the study (for the lip creams). Subjects were excluded if they were under a physician's care or were taking any medication that might mask or interfere with the test results. Those who had a history of skin cancer, melanoma, lupus, psoriasis, connective tissue disease, diabetes, or any disease that would increase risk associated with study participation were excluded. Women who were pregnant, lactating, intending to become pregnant during the study period, or had given birth during the previous six months were excluded. Subjects were excluded if they had chronic skin allergies or a history of hypersensitivity to cosmetics in general. Further exclusion criteria included neurologic, dermatologic, or systemic disorders that would interfere with the results. Smokers, patients who had dermal filler injected into the lips or had fat grafting, silicone injections, or implants in the lips during the previous year were also excluded. Subjects who had botulinumtoxin type A around the lips during the previous six months, had laser resurfacing, chemical peels, or dermabrasion done to the lips were excluded. Finally, patients with lip disease, previous lip surgery, or systemic disease (e.g., diabetes, scurvy, or chelitis) were excluded. All subjects provided signed, informed consent to participate in the study. Test product. Each of the five test products contained the anti-aging ingredients of the technology platform (Table 2) at concentrations known to be efficacious. To be clear, not all of the ingredients used in the platform were present in each product, but some combinations of each were used. Table 2 represents the common tradenames; any single TABLE 1. Demographics of test product populations TEST PRODUCT CREAM AGE RANGE CAUCASIAN HISPANIC Day facial 42–51 years 4 1 Night facial 34–56 years 5 none Eye 38–51 years 5 none Day lip 46–54 years 5 none Night lip 46–55 years 5 none TABLE 2. Ingredients of test products Cromoist™ CM glucan Vitamin E (tocopheryl acetate) Vitamin E (tocopheryl acetate) White tea extract Liquorice extract Niacinamide Zinc citrate Hexapeptide-3 (argireline) Dermaxyl Dermaxyl Haloxyl Sepilift Eyeliss Rigin Maxilip Ederline L Silymarin (milk thistle, 80%) Caffeine Dexpanthenol (vitamin B5) Cucumber extract Ivy extract Shitake extract Allantoin Avocado oil/sterol Avocado butter White petrolatum Illilpe butter Shea butter Shora seed butter Ceraphyl 847 C12-15 alkyl benzoate Pentaerythrityl tetraisostearate Diisopropyl adipate Evening primrose FIGURE 1. Outer view of a Novasome—Inside are 2 to 7 bilayer membranes surrounding a large "cargo hold" that can carry multiple active ingredients. FIGURE 2. Most liposomes consist of concentric membranes with a solid core (right). The left cutaway illustration of a Novasome shows the membranes that surround the inner chamber, or "cargo hold."

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