Journal of Clinical and Aesthetic Dermatology

OCT 2017

An evidence-based, peer-reviewed journal for practicing clinicians in the field of dermatology

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15 JCAD joURnAL oF CLiniCAL And AesTHeTiC deRMAToLogy October 2017 • Volume 10 • Number 10 O R I G I N a L R E S E a R C H superior healing. Finally, the unique, natural preservative system likely contributed to the excellent safety and tolerability profile. The positive results of this study give rise to consideration of the applicability of topical CLa in other disorders of impaired cutaneous barrier function and increased cutaneous inVammation. Pilot studies suggest a potential positive impact of CLa on atopic dermatitis and rosacea. 13,14 Since the present study has shown that this compound is safe on laser-damaged skin, which had all barrier function stripped and intense inVammatory conditions iatrogenically applied, other dermatitides, such as atopic dermatitis and radiation dermatitis, might also benefit from the healing and anti-inVammatory capabilities of topical CLa. Limitations. The limitations of this study include the relatively small sample size, as well as the slight variations in laser treatment settings. Given that this was a clinical aesthetic study, the unique features of each individual subject were taken into account when selecting the most appropriate treatment settings. The treating and evaluating investigators were blinded to the post-procedure regimen throughout the duration of the study. ReFeRenCes 1. Fitzpatrick RE, Williams b, and Goldman MP, Preoperative anesthesia and postoperative considerations in laser resurfacing. Semin Cutan Med Surg. 1996;15(3): 170–176. 2. Ratner D, Tse Y, Marchell N, et al. Cutaneous laser resurfacing. J Am Acad Dermatol. 1999;41(3 Pt 1):365–389; quiz 390–392. 3. Fitzpatrick RE, Goldman MP, Satur NM, Tope WD. Pulsed carbon dioxide laser resurfacing of photo-aged facial skin. Arch Dermatol. 1996;132(4):395-402. 4. Manuskiatti W, Fitzpatrick RE, Goldman MP. Long-term eSectiveness and side eSects of carbon dioxide laser resurfacing for photoaged facial skin. J Am Acad Dermatol. 1999;40(3):401–411. 5. Qian LW, Fourcaudot ab, Yamane K, et al. Exacerbated and prolonged inVammation impairs wound healing and increases scarring. Wound Repair Regen. 2016;24(1):26–34. 6. Weiss Ra, Goldman MP. Interpenetrating polymer network wound dressing versus FigURes 2A–d. blinded investigator evaluation of healing post-ablative laser resurfacing of the face; no significant differences detected between the two groups in a) erythema, b) edema, C) crusting, and D) exudation, as evaluated by a blinded investigator; all data represented as mean ± standard deviation A C d b

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