Journal of Clinical and Aesthetic Dermatology

OCT 2017

An evidence-based, peer-reviewed journal for practicing clinicians in the field of dermatology

Issue link: http://jcadonline.epubxp.com/i/900562

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14 JCAD joURnAL oF CLiniCAL And AesTHeTiC deRMAToLogy October 2017 • Volume 10 • Number 10 O R I G I N a L R E S E a R C H results remained similar between the two groups (Figure 4). Subjects were satisfied to extremely satisfied with the outcomes of both healing regimens (Figure 5). disCUssion Improvements in "healability" represent important advances in achieving optimal outcomes following ablative procedures. In this study, we demonstrated the safety and efficacy of a novel anti-inVammatory, anti-oxidant topical healing regimen based on conjugated linolenic acid derived from pomegranate oil extract. Whereas this compound had previously demonstrated experimental efficacy in a range of inVammatory disorders, the data presented in this study are the first to explore the role of CLa when applied directly to damaged and inVamed skin in a clinical setting. 8–13 In these preliminary data, topical CLa does not raise any safety or tolerability issues when compared to current standard of care. Furthermore, the topical CLa formulation outperformed current wound care standards by decreasing acute pruritus and enabling a faster positive outcome in wrinkle improvement. There are several features of this topical healing regimen that potentially contributed to the positive results. Firstly, the anti- inVammatory and anti-oxidant nature of the CLa and other omega-5 fatty acids might have facilitated the acute stages of wound healing. Secondly, the occlusive ointment-based delivery system enabled regulation of temperature, humidity, and moisture balance within the local wound healing environment resulting in FigURes 1A–e. Subject evaluation of adverse side effects post-ablative laser resurfacing of the face: a) pain, b) itching, C) crusting, D) tightness, and E) oozing; a 10-point visual analog scale used at each follow up time point; aside from significant reduction in itching at Day 1 post-procedure in the Pomega TM group (p<0.05), there were no statistical differences between test and control groups; all data represented as mean ± standard deviation A b C d e

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