Journal of Clinical and Aesthetic Dermatology

AUG 2017

An evidence-based, peer-reviewed journal for practicing clinicians in the field of dermatology

Issue link: http://jcadonline.epubxp.com/i/870497

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59 JCAD JOURNAL OF CLINICAL AND AESTHETIC DERMATOLOGY august 2017 • Volume 10 • number 8 O r i g i n a l r e s e a r c h TABLE 1. main studies published in the last 5 years on the treatment of onychomycosis NUMBER OF PATIENTS/NAIL P LATES LASER T YPE CLINICAL/LABORA- T ORY FOLLOW-UP RESULTS REFERENCE 10 patients, 14 plates 1 064nm nd:yag laser (16J/cm²/0.3ms) 5 sessions 24 weeks 8 plates—improvement through the Osi 2 patients—mycological cure carney et al, 2010 12 36 patients 870/930nm 4 sessions-60 days 36 weeks 40% of clinical and mycological cure landsman et al, 2010 17 72 patients, 194 plates 1064nm nd:yag laser (long pulse) 4 sessions-7 days 3, 6, 9, and 12 weeks 100% of clinical and mycological cure Kozarev & Vizintin, 2010 2 4 11 patients 1064nm nd:yag laser (223J/cm²/0.65ms) 2 to 3 sessions-21 days 24 weeks mycological cure in 7 of 8 hochman et al, 2011 2 7 13 patients, 73 plates 1064nm nd:yag laser (short pulse) 1 to 3 sessions-30 to 60 days 24 weeks 19 plates—clinical and mycological cure Kimura et al, 2012 22 12 patients, 57 plates 10 controls, 68 plates 1064nm nd:yag laser 5J/cm²/0.3ms 2 sessions-15 days 12 and 48 weeks there was no statistical difference hollmig et al, 2013 5 12 patients long pulse nd:yag laser (10J/cm²/0.5ms) 3 sessions-28 days 12 and 24 weeks 3 patients—clinical cure noguchi et al, 2013 28 20 patients (10 right foot and 10 left foot) 1064nm nd:yag laser long pulse and short pulse 2 sessions-30 days 36 weeks mycological cure in 6 long pulse and 7 short pulse hess et al, 2013 29 131 patients 1064nm/532nm Q-switched 2 sessions-30 days 12 weeks 95.4% clinical and mycological cure Kalokasidis et al, 2013 23 120 patients (3 children) 1064nm nd:yag laser Q-switched (600mJ/cm²) 1 session 36 weeks 100% of clinical and mycological cure garcia, 2014 18 24 patients cO 2 3 sessions-30 days + amorolfine cream 24 weeks 50% of clinical and mycological cure li et al, 2014 6 10 patients 10 controls with cryogen 1320nm nd:yag laser 4 sessions 12 weeks 45%—linear growth there was no significant difference Ortiz et al, 2014 7 37 patients, 112 plates 39 patients, 118 plates (itracona- nd:yaD long pulse 8, 16, and 24 weeks itraconazole greater efficacy with 8 and 16 weeks, but equal at 24 weeks li et al, 2014 6 24 patients Diode 1064nm (5J/cm 2 /80ms) 2 to 3 sessions-60 days 12 weeks 6 patients—clinical and mycological cure Osi—40% improvement rener et al, 2015 30 30 patients 1064nm nd:yag laser short pulse 48 weeks 20 patients—clinical and mycological cure helou et al, 2016 19 Osi: Onychomycosis severity index; nd:yag: neodymium-doped yttrium aluminum garnet

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