Journal of Clinical and Aesthetic Dermatology

AUG 2017

An evidence-based, peer-reviewed journal for practicing clinicians in the field of dermatology

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39 JCAD JOURNAL OF CLINICAL AND AESTHETIC DERMATOLOGY august 2017 • Volume 10 • number 8 B r i E F r E p o r T controlled, randomized studies evaluating the effectiveness of cHlcu c ombined with urea, lipids, antioxidants, and humectants (rejuvaphyl® Hand and neck complex) in reducing signs of photoaging are needed before meaningful conclusions can be drawn. However, our preliminar y results suggest this combination therapy has potential as a rejuvenation treatment. REFERENCES 1. Jakubietz rG, Jakubietz MG, kloss d, Gruenert JG. defining the basic aesthetics of the hand. Aesthetic Plast Surg. 2005;29:546–551. 2. Jakubietz rG, kloss dF, Gruenert JG, Jakubietz MG. The aging hand. a study to evaluate the chronological ageing process of the hand. J Plast Reconstr Aesthet Surg. 2008;61:681–686. 3. koscinski k. Hand attractiveness-its determinants and association with facial attractiveness. Behav Ecol. 2012;23:334–342. 4. Bains rd, Thorpe H, southern s. Hand aging: patient's opinions. Plast Reconstr Surg. 2006;117:2212–2218. 5. Fenske na, lober cW. structural and functional changes of normal aging skin. J Am Acad Dermatol. 1986;15:571–585. 6. shamban aT. combination hand rejuvenation procedures. Aesth Surg J. 2009;29:409–413. 7. Fabi sG, Goldman Mp. Hand rejuvenation: a review and our experience. Dermatol Surg. 2012:38:1112–1127. 8. Butterwick kJ. rejuvenation of the aging hand. Dermatol Clin. 2005;23:515–527. 9. Gold MH, Gallagher c. an evaluation of the benefits of a topical treatment in the improvement of photodamaged hands with age spots, freckles, and/or discolorations. J Drug Dermatol. 2013;12:1468–1472. 10. schlessinger J, saxena s, Mohr s. assessment of a novel anti-aging hand cream. J Drugs Dermatol. 2016;15:496–503. 11. Brett dW. chlorophyllin-a healer? a hypothesis for its activity. Wounds. 2005;17:190–195. 12. Tumolo T, lanfer-Marquez UM. copper chlorophyllin: a food colorant with bioactive properties? Food Res Int. 2012;46:451–459. 13. kamat Jp, Boloor kk, devasagayam Tpa. chlorophyllin as an effective antioxidant against membrane damage in vitro and ex vivo. Biochimica et Biophysica Acta. 2000;1487:113–127. 14. lopez-carballo G, Hernandez-Munoz p, Gavara r, ocio MJ. photoactiviated chlorophyllin-based gelatin films and TABLE 2. case 2 PHOTODAMAGE PARAMETERS SCORE 0=NONE, 1–3=MILD, 4–6=MODERATE, 7–9=SEVERE BASELINE SCORE POST 9TREATMENT SCORE Fine lines/wrinkles 8 7 Tactile roughness 7 5 skin tone unevenness 8 6 Mottled pigmentation 8 6 Global Improvement 0 = Worse 1 = no improvement 2 = Mild improvement 3 = Moderate improvement Xx 4 = Marked improvement FIGURE 3. case 2, a 59-year-old woman with severe photodamage of the hands treated for 12 weeks. standard view, baseline (left) and at Week 12 (right) FIGURE 4. case 2. cross-polarized view (brown channel), baseline (left) and at Week 12 (right) 3

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