Journal of Clinical and Aesthetic Dermatology

AUG 2017

An evidence-based, peer-reviewed journal for practicing clinicians in the field of dermatology

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33 JCAD journAl oF clinicAl And Aesthetic derMAtology August 2017 • Volume 10 • number 8 o r i G i n A L r e s e A r c h 59 were compared with counts at baseline. treatment with ingenol mebutate gel 0.015% reduced the mean (sD) Ak count by 76 percent, from 11.3 (5.2) at Day 0 to 2.7 (2.68) at Day 59 (P<0.001) (Figure 1). Quantitative analysis of photoaging. the six individual aspects of photoaging described above as well as seborrheic keratoses were assessed by the investigator with the modified Alexiades-Armenakas comprehensive grading scale at baseline (Day 0) and after application of ingenol mebutate on Days 24 and 59 (Figure 2). Grades for all six signs of photodamage were significantly lower after ingenol mebutate gel treatment at Day 59 as compared with baseline. the largest point decrease after treatment (1.7) was observed for "texture," from a mean grade of 3.0 at baseline to 1.3 at Day 59. subject satisfaction with skin improvement. subjects completed a survey that assessed their overall satisfaction with improvement in photoaging as well as their satisfaction with improvement in five individual characteristics of photoaged skin on Days 10, 17, 24, and 59. At Day 59, the most frequently cited satisfaction score was "6, completely satisfied" (Figure 3); less than 60 percent of the subjects indicated that they were "moderately satisfied" or "completely satisfied" with improvements in signs of photoaging. the mean and standard error of the mean (sem) scores for subject satisfaction increased from Day 10 to Day 59 for the six characteristics of photoaging to a score tAble 1. baseline characteristics DemoGrAPhic sUbjects (n=21) Female (n, %) 18 (86%) male (n, %) 3 (14%) Age (y) mean (sD) median (range) 59.1 (7.3) 60 (41–69) Ak count mean (sD) median (range) 11.3 (5.2) 10 (5–24) sD=standard deviation. tAble 2. rates of actinic keratosis (Ak) clearance strAtiFicAtion oF sUbjects by Ak cLeArAnce sUbjects (n=20), n (%) complete clearance (100%) 6 (30) Partial clearance (≥75%)* 10 (50) mild clearance (≥10% and <75%) 10 (50) *includes subjects with complete clearance. Figure 1. reduction in actinic keratosis (Ak) counts before ingenol mebutate gel 0.015% treatment (baseline) and at Day 59 Figure 2. Physician evaluation of graded signs of photodamage/skin aging before ingenol mebutate gel 0.015% treatment (baseline) and at Day 59 Mean AK Count (SEM)

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