Journal of Clinical and Aesthetic Dermatology

JUN 2017

An evidence-based, peer-reviewed journal for practicing clinicians in the field of dermatology

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43 JCAD journal of clinical and aesthetic dermatology June 2017 • Volume 10 • Number 6 P O S t P H O C A N A L Y S I S and BP provides superior efficacy to each of the individual active ingredients, 1 3 it is not possible to determine the contributions from the individual active ingredients in the authors' analysis. In addition, the Phase 3 study was not designed to specifically investigate the efficacy of clindamycin 1.2%/BP 3.75% gel in Hispanic patients. CONCLUSION The results of the authors' post- hoc analysis suggest that a fixed combination of clindamycin 1.2%/BP 3.75% gel may be an effective, safe, and well-tolerated topical treatment for use in Hispanic patients with moderate- to-severe acne. ACKNOWLEDGMENT The authors thank Brian Bulley, MSc (Konic Limited, UK) for assistance with the preparation of the manuscript. Valeant Pharmaceuticals funded Konic's activities pertaining to this manuscript. REFERENCES 1. Sanchez MR. Cutaneous diseases in L atinos. Dermatol Clin. 2003;21:689– 697. 2. Taylor SC. Skin of color: biology, structure, function, and implications for dermatologic disease. J Am Acad Dermatol. 2002;46(Suppl 2):S41– S62. 3. Perkins AC, Cheng CE, Hillebrand GG, et al. Comparison of the epidemiology of acne vulgaris among Caucasian, Asian, Continental Indian and African American women. J Eur Acad Dermatol Venereol. 2011;25(9):1054–1060. 4. Callender VD. Considerations for treating acne in ethnic skin. Cutis. 2005;76(Suppl 2):S19–S23. 5. Taylor SC. Utilizing combination therapy for ethnic skin. Cutis. 2007;80(Suppl):15–20. 6. Alexis AF. Acne vulgaris in skin of color: understanding nuances and optimizing treatment outcomes. J Drugs Dermatol. 2014;13(Suppl 6):S61–S65. 7. Callender VD. Acne in ethnic skin: special considerations for therapy. Dermatol Ther. 2004;17(2):184– 195. 8. Habif TP. Clinical Dermatology. 5th ed. St.Louis, MO: Mosby; 2010. 9. Cole PD, Hatef DA, Taylor S, et al. Skin care in ethnic populations. Semin P last Surg. 2009;23:168–172. 10. Pariser DM, Rich P, Cook-Bolden, FE, et al. An aqueous gel fixed combination of clindamycin phosphate 1.2% and benzoyl peroxide 3.75% for the once-daily treatment of moderate to aevere acne vulgaris. J Drugs Dermatol. 2014;13(9):1083– 1089. 11. Cook-Bolden FE. Treatment of moderate to severe acne vulgaris in a Hispanic population: a post-hoc analysis of efficacy and tolerability of clindamycin phosphate 1.2%/benzoyl peroxide 2.5% gel. J Drugs Dermatol. 2012;11(4):455–459. 12. Fernandez-Obregon A, Davis MW. The BEST study: evaluating efficacy by selected demographic subsets. Cutis. 2003;71(2 Suppl):18–26. 13. Thiboutot D, Zaenglein A, Weiss J, et al. An aqueous gel fixed combination of clindamycin phosphate 1.2% and benzoyl peroxide 2.5% for the once-daily treatment of moderate to severe acne vulgaris: assessment of efficacy and safety in 2813 patients. J Am Acad Dermatol. 2008;59s:792–800.

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