Journal of Clinical and Aesthetic Dermatology

JUN 2017

An evidence-based, peer-reviewed journal for practicing clinicians in the field of dermatology

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20 JCAD journal of clinical and aesthetic dermatology June 2017 • Volume 10 • Number 6 Pearson's chi-square test was used for categories with expected cell size greater than 5, and Fisher's exact test was used for categories with expected cell counts of 5 or less; for situations in which the participant was able to choose more than one response, a chi- square test was repeated for each response level. No adjustment was made to correct for multiple testing. Analyses were performed on the population of evaluable participants, which comprised eligible respondents who completed the survey in its entirety. RESULTS Participants. A total of 4,174 individuals responded to the e-mail invitation and opt-out link, of whom 659 were eligible to participate; 600 participants completed the survey (Figure 1). Common reasons for ineligibility included having "no signs of unwanted redness," being "almost clear of unwanted redness," lack of a physician's diagnosis, having telangiectasia covering more than 25 percent of the rosacea-affected areas, or having sun-damaged skin covering more than 25 percent of the face. Of the eligible subjects completing the survey, 409 were included in the ETR cohort and 191 in the PPR cohort. Sociodemographics are shown in Table 1. The mean age was 51.7 (standard deviation, 13.91) years, with participants in the PPR cohort approximately 4.4 years older on average than those in the ETR cohort (p=0.0003). More than half (69.5%) of participants were female and more than 95 percent were Caucasian. Participants in the PPR cohort had significantly less prescription drug coverage and private medical insurance than those in the ETR cohort (p=0.003). Clinical characteristics of the participants are shown in Table 2. Ninety-three percent of participants had a Fitzpatrick skin phototype of I, II, or III. The most common concomitant skin conditions were eczema and psoriasis, which were reported by 16.7 percent and 9.0 percent of all participants, respectively; 72.5 percent had no other skin condition. Among participants who could recall, they first noticed rosacea signs and symptoms at a mean age of 37.9 years. For eligible participants, a mean of 9.3 years elapsed between diagnosis and screening. Patients in both cohorts gave similar severity ratings; 95.6 percent (391/409) of participants in the ETR cohort and 93.7 percent (179/191) in the PPR cohort rated their rosacea as mild or moderate. Only 8.9 percent of participants could recall the clinical rosacea subtype with which they were diagnosed. Rosacea symptoms. The predominant initial rosacea sign and/or symptom in both cohorts was persistent facial redness, reported by 71.5 percent of participants (Figure 2A). As expected, significantly more participants in the PPR cohort reported bumps or pimples as the initial rosacea symptom than those in the ETR cohort (p<0.0001). O R I G I N A L R E S E A R C h Figure 1. Disposition of survey respondents. ETR=erythematotelangiectatic rosacea; PPR=papulopustular rosacea

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