Journal of Clinical and Aesthetic Dermatology

APR 2017

An evidence-based, peer-reviewed journal for practicing clinicians in the field of dermatology

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21 JCAD journal of clinical and aesthetic dermatology April 2017 • Volume 10 • Number 4 unsatisfied (Table 5 and Figure 5, respectively). Results regarding the characteristics of the product including comfort under makeup, feel on the skin, speed of absorption, texture, color, and odor yielded a very good satisfaction rate. No adverse experiences or events occurred during the course of the trial. DISCUSSION In the results presented here, treatment with the herbal-based face cream significantly improved all evaluated parameters of seborrheic dermatitis when compared to baseline while presenting no safety concerns. In previous studies concerning treatment of SD, there is a lack of standard agreed criteria for treatment outcome assessment. Variables used to assess outcome have included pruritus, desquamation, induration, erythema, and ISGA. 12–19 This investigation used all these criteria as well as patient self-assessment questionnaires to obtain a more complete picture of the efficacy and safety of the cream. In addition, a vehicle-controlled study would be a further step in better demonstrating the efficacy of the study medication. This design will be added to future investigations. In today's world there is often an increasing demand for alternative 17 and herbal/botanical- based treatments. SD has been successfully treated with aloe vera 12 in a study involving 46 patients who received treatment with 30% aloe vera twice a day or placebo for six weeks. According to the dermatologist rating, there was a 58-percent improvement (as compared to 15% improvement in the placebo group). While patients reported 62-percent improvement (as compared to 25% to the placebo group). In addition, tea tree oil shampoo has been shown to have antifungal activity and is clinically effective in treating dandruff thought to be caused by the yeast Pityrosporum ovale. 16 The herbal-based face cream used in this study forms a dense layer over the skin-injured areas and prevents oxygen supply. The resulting anaerobic conditions inhibit pathogen growth. In addition, the strong barrier properties of the cream isolate and protect the inner layers of epidermis from desiccation. Moreover, the herbal ingredients in the cream, and mostly the dipotassium glycyrrhizate (also known as licorice), offers potential anti- o R I G I n A L R E S E A R C H Figure 3. Average pruritus self-evaluation improvement (percentage compared to BL) versus duration (weeks from BL) table 3. Average pruritus self-evaluation improvement on Weeks 2, 4, and 6 durAtion dnuMber of Weekse Pruritus iMProVeMent d%e 2 80.8 4 88.5 6 94.9

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