Journal of Clinical and Aesthetic Dermatology

APR 2017

An evidence-based, peer-reviewed journal for practicing clinicians in the field of dermatology

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20 JCAD journal of clinical and aesthetic dermatology April 2017 • Volume 10 • Number 4 o R I G I n A L R E S E A R C H R E - significantly improved from baseline. In addition, clear improvement was visually evident (Figure 1). Specifically, ISGA improved 76 percent after six weeks of treatment with the product (p<0.05 compared to baseline [BL]). The mean score changed from 2.35 at baseline to 0.54 after six weeks. The largest percent improvement in all parameters occurred between baseline and Week 2, suggesting a fast onset of action. Average desquamation was improved by 85 percent following four weeks of treatment (p<0.05 compared to BL), while the mean score changed from 1.76 at baseline to 0.38 after six weeks. Average improvement in induration reached 92.9 percent after six weeks of product treatment (p<0.05 compared to BL). The mean scores changed from 1.69 at baseline to 0.15 after six weeks. Average improvement in erythema reached 77.6 percent after six weeks of product treatment (p<0.05 compared to BL). Mean scores changed from 2.42 at baseline to 0.50 after six weeks. Average improvement of pruritus reached 94.9 percent following six weeks of treatment, based on the subject statements (p<0.05 compared to BL) and the mean scores changed from 2.03 at baseline to 0.15 after six weeks (Tables 2 and 3; Figures 2 and 3, respectively). As can be seen from the following figures, the evaluated parameters not only maintained their improvement, but also continued to show additional improvement until the end of the six-week study. When asked how they liked the product, 76 percent of the subjects liked the product extremely well; 24 percent liked it really well; and 0 percent somewhat liked it, neither liked nor disliked it, or did not like the product (Table 4 and Figure 4, respectively). When asked how satisfied they were with the speed of the improvement provided by the product, 65 percent responded very satisfied; 35 percent moderately satisfied; and 0 percent satisfied, moderately satisfied, or very T a b l e 2 . improvement achieved in the evaluated parameter: isGA, desquamation, induration, and erythema on Weeks 2, 4, and 6 durAtion dnuMber of Weekse isGA iMProVeMent d%e desquAMAtion iMProVeMent d%e indurAtion iMProVeMent d%e ery theMA iMProVeMent d%e 2 57.7 61.5 82.7 53.8 4 69.9 85.3 89.7 69.2 6 76.3 80.1 92.9 77.6 Figure 2. Average treatment score versus duration (weeks)

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