Journal of Clinical and Aesthetic Dermatology

APR 2017

An evidence-based, peer-reviewed journal for practicing clinicians in the field of dermatology

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19 JCAD journal of clinical and aesthetic dermatology April 2017 • Volume 10 • Number 4 o R I G I n A L R E S E A R C H occasionally disturbs sleep), and 4=severe and constant itching. Subjects were instructed to use the study face cream twice a day, morning and evening, for a consecutive period of 42 days. In addition to the baseline visit (Day 0), subjects visited the clinic for two follow-up visits at Days 14 and 28 and for a final visit at Day 42. A flexibility of ±2 days was allowed. In case of an adverse event, the subject was asked to immediately contact the clinic and to come to an unscheduled visit if needed. At each of the two follow-up visits and at the final visit, the investigator evaluated the overall severity of seborrhea (ISGA) and the target area's desquamation, induration, and erythema. At each visit, the subjects assessed their pruritus over the past 24 hours. At the final visit, the subject completed a product assessment questionnaire. The questionnaire included several questions about satisfaction attributes, using a 5- point scale: -2=very unsatisfied, -1=unsatisfied, 0=neutral, +1=satisfied, +2=very satisfied. Attributes included overall satisfaction, speed of results, ease of use, ease of spread, comfort under makeup, feel on the skin (- 2=very greasy, +2=very moisturizing), speed of absorption, texture, color, and odor. RESULTS A total of 32 patients were recruited to the study. Six patients left the study due to personal reasons not connected to the study itself, leaving 26 patients who completed the study (Table 1). Results from each visit were compared with those from baseline using the Nonparametric Dunn Test. Analysis results showed statistically significant differences (reduction) between all tested pairs when compared to baseline (parameters and visit considering an alpha level of 5% in the probability distribution plot), which supports the hypothesis that symptoms improve with each visit. In general, all evaluated parameters at all timepoints showed significant clinical improvement when compared to baseline. Only desquamation between Weeks 4 and 6 did not show a significant improvement from Week 4 to Week 6, even though each of these timepoints table 1. Patient demographic characteristics ChArACteristiCs VAlue Men 20 (77%) Women 6 (23%) Age range (years) 25–85 Mean Age (years) 61.1 (deviation 13.4) Figures 1A and 1B. Clinical appearance of patient with sebhorrheic dermatits (A) before and (B) after 6 weeks of treatment with a novel herbal-based cream A B

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